TLR4 Activity in the Gut Contributes to Symptoms in Chronic Fatigue Syndrome!

"Interactions between gut microorganisms and host immune function have been shown to contribute to aberrant inflammation in CFS/ME patients. Commensal and/or pathogen-associated molecular patterns detected by Toll-like receptors (TLRs) expressed on intestinal epithelial cells appear to trigger inflammatory signaling cascade leading to neuroinflammation and neurodegeneration."

The Role of Toll-like Receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A New Promising Therapeutic Approach? CNS & neurological disorders drug targets (25 March 2015) by M. E. Gambuzza, F. M. Salmeri, L. Soraci, et al.  http://www.citeulike.org/user/kimberlykramer2015/article/13568646


For further reading:
Infection/Endotoxin in Chronic Fatigue, Fibromyalgia and Multiple Chemical Sensitivity.