A recent study showed that the satiety protein, apolipoprotein, is blocked by inflammatory cytokines produced after a high-fat meal. In this study, the researchers found that gene expression was reduced because of the presence of inflammatory cytokines Il-6 and TNF-a before feeding linoleic acid, an important fatty acid. From the results of this study, the researcher's concluded that pro-inflammatory cytokines inhibit the natural satiety feeling and contribute to diet-induced obesity.
TNF-alpha and IL-6 inhibit apolipoprotein A-IV production induced by linoleic acid in human intestinal Caco2 cells 7th Space (22 March 2015) by Xiaoming LiMin, XuMin LiuYong, JiZhongfang Li. http://www.citeulike.org/user/kimberlykramer2015/article/13582730
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