Mycotoxins Effects Are Worse When Combined!

 "Nivalonal and Deoxynivalenol are tow mycotoxins that are found in human food and animal feed. According to a new study, these two mycotoxins causes an increased amount of oxidative stress. Much more than is what is normal for cellular metabolism. The researchers found during the study that nivalenol as compared to deoxynivalenol is the stronger pro-oxidant of the two. However, when combined nivalenol increases deoxynivalenol pro-oxidative effects. This is achieved through activation of a number of pathways including NF-KB and the Nrf2. Both of which I have discussed in other blogs.  The authors make the comment that the negative effects of mycotoxins combined should be considered during risk assessments."

Nivalenol induces oxidative stress and increases Deoxynivalenol pro-oxidant effect in intestinal epithelial cells. Toxicology and applied pharmacology (13 April 2015) by Marisanta Del Regno, Simona Adesso, Ada Popolo, et al. http://www.citeulike.org/user/kimberlykramer2015/article/13586502