In other posts, I have noted that one way to reduce the effects of environmental illnesses is to maintain a healthy diet that is low in fat. The main reasons for this is that high fat diets (HFD) 1) lead to dysbiosis. In other words, an unhealthy gut full of unhealthy gut bacteria and 2) HFD leads to obesity, more oxidative stress and inflammation that can lead to diabetes. (1-2) Of course, since many patients with environmental illnesses already have higher oxidative stress. Anything that increases it is just going to make symptoms worse.
According to one recent study out of Chicago, researchers demonstrated that a HFD alters gut bacteria that makes fat gain easier. What they found is that "germ free" mice did not gain weight even when fed a HFD. On the other hand, mice with a "normal intestinal environment" and fed a HFD had an increase in bacteria that alter fat absorption and a decrease in bacteria linked to leanness. (3)
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*High-fat diet inhibits PGC-1α suppressive effect on NFκB signaling in hepatocytes. European journal of nutrition, Vol. 57, No. 5. (August 2018), pp. 1891-1900 by Wermerson Assunção A. Barroso, Vanessa Jacob J. Victorino, Isabela Casagrande C. Jeremias, et al.
1) Systemic low-grade inflammation is related to both circulating and adipose tissue TNFalpha, leptin and IL-6 levels in obese women. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, Vol. 28, No. 8. (August 2004), pp. 993-997 by M. Maachi, L. Piéroni, E. Bruckert, et al.
2. High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. PloS one, Vol. 5, No. 8. (16 August 2010) by Shengli Ding, Michael M. Chi, Brooks P. Scull, et al.
3).Gut bacteria Could Be One Reason a Junk Food Diet Makes Us Put on Weight. Sam Downing. Coach. Nine. Com. Au. April 12, 2018. https://coach.nine.com.au/2018/04/12/10/07/gut-bacteria-high-fat-diet
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