In past blogs, we have discussed the many benefits of eating broccoli which contains the isothiocyanate sulforaphane. Past discussions have focused on how it may reduce inflammation that leads to cancer and depression and be beneficial in the treatment of other diseases. It has now been shown that it acts directly on the inflammasome NLRP3 by inhibiting the maturation of Il-1b. Interestingly, this discovery represents a new pathway for sulfurophane's action because in this case, its action is independent of Nrf2. (2)
A recent study has demonstrated that in a mouse model of chronic fatigue syndrome, fatigue was caused by activation of the inflammasome NLRP3. Inflammasomes are sensing protein complexes that are part of the immune response. that eventually produces Il-1 and Il-6. In the model, mice were exposed to an LPS challenge and a swim test. After the experiment, test mice showed an increase of both Il-1 and Il-6 in the brain and behaviorally, slower motor responses. The author wrote, "LPS-induced fatigue is an Il-1-dependent process and the NLRP3/caspase-1 pathway is involved in the mechanism of LPS-induced fatigue behaviors. NLRP3/caspase-1 inhibition may be a promising therapy for fatigue treatment. " (1)
Related Posts:
*Depression in Environmental Illness May Be Relieved by Eating Broccoli!
* Nrf2 and inflammasomes.
1. Activation of the NLRP3 inflammasome in lipopolysaccharide-induced mouse fatigue and its relevance to chronic fatigue syndrome. Journal of neuroinflammation, Vol. 13, No. 1. (05 April 2016) by Zi-Teng T. Zhang, Xiu-Ming M. Du, Xiu-Juan J. Ma, et al. http://www.citeulike.org/user/kimberlykramer2015/article/14620278
2. Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism. Journal of leukocyte biology, Vol. 99, No. 1. (January 2016), pp. 189-199 by Allison J. Greaney, Nolan K. Maier, Stephen H. Leppla, Mahtab Moayeri.
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