Good Memory Depends On The Health Of Your Gut!

"Researchers have been conducting studies to determine how gut health and problems affect the body. Individuals who want to improve their memory may take into account taking better care of their gut." Read more...

Research Now Shows Gut Health Influences Good Memory. Melissa Scott Newswire. October 17, 2018

Stomach Reflux Medications May Alter Gut Biome!

"Proton pump inhibitors (PPIs) are one of the most commonly used medications for gastrointestinal (GI) disorders, but are often taken for far longer periods of time than they are FDA-approved for and sometimes at higher doses. To assess this trend, Cleveland Clinic researchers were invited by Nutrition in Clinical Practice to review the literature on the proper use of PPIs and potential side effects, including emerging effects on the gut microbiome. " Read article...

Long-term Use of PPIs Has Consequences for Gut Microbiome. Consult QD. September 19, 2018.

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Gut Flora Changes In Alzheimer's May Lead to Endotoxemia!

"Alterations in gut microbiota in patients with Alzheimer's disease (AD) may be associated with increased bacterial endotoxins in the blood, a finding that may point the way to potential treatments, new research suggests." Read more...

Gut Microbiota Signature Altered in Alzheimer's Disease . Liam Davenport. Medscape.
October 11, 2018

Strong Link Between Gut Biome and Multiple Sclerosis Found!

"Summary: A new study reports T cells are activated in the intestines and migrate to the brain, causing an inflammatory cascade that may lead to multiple sclerosis. Researchers say the gut microbiome may play a more significant role in the development and progression of MS than previously believed." Read more...

Link Between Gut Flora and Multiple Sclerosis Discovered. Neuroscience News October 11, 2018

Artificial Sweeteners May Negatively Impact Glucose Levels By Altering Gut Biome!

"Low-calorie sweeteners appear to impair glucose uptake and control by disrupting the gut microbiome, Australian researchers have shown for the first time in findings that suggest artificial sweeteners could potentially play havoc with glucose-lowering medications in patients with diabetes." Read article...

Sweeteners Disrupt Blood Glucose Via Effects on Gut Bacteria. Liam Davenport. Medscape.
October 09, 2018

Artificial Sweeteners Have Toxic Effects On The Gut Biome!

"A new study reports FDA approved artificial sweeteners and some sports supplements are toxic to digestive gut bacteria. Researchers say the consumption of artificial sweeteners can adversely affect gut microbial activity, causing a wide range of health issues from cancers to type-2 diabetes." Read more...

Artificial Sweeteners Have Toxic Effects on Gut Bacteria. Neuroscience News October 1, 2018.

Pomegranate As Part Of A Healthy Diet May Prevent "Leaky Gut"!

Photo by Charles Deluvio 🇵🇭🇨🇦 on Unsplash

In a recent study, it was demonstrated that ingestion of pomegranates for 10 days led to a decrease in gut leakiness, endotoxemia and inflammatory liver damage from binge drinking. Although most people do not binge drink, it is safe to assume that adding pomegranate to one's diet may help prevent anything that causes "leaky gut syndrome". Just a few of these causes include bacterial infections,
Western-type diets and high sugar diets. "Leaky gut" has been implicated in a number of health conditions including chronic fatigue syndrome, fibromyalgia, inflammatory bowel disease, diabetes and many others.

The results of this study showed:

1. POM protected the alcohol-induced gut leakiness and inflammatory liver injury through suppressing the nitroxidative stress with elevated levels of CYP2E1, iNOS and nitrated proteins in the intestines and livers of the alcohol-exposed rats. 
2. POM pretreatment prevented hepatic injury, fat accumulation, nitroxidative stress and ER stress and inflammation response in the liver and allowed for blockade of gut leakiness in alcohol-exposed rates. 
3.  Pretreatment with an individual compound of POM EA or UA significantly reduced the elevated levels of CYP2E1, iNOS and nitrated proteins as well as the mRNA transcripts of NLRP3, IL-1β, and TNF-α in alcohol-exposed AML12 liver cells.
4. Protected against tight junction disfunction by increasing tight junction proteins. 
5. The author believes that the reduction of CYP2E1 prevented gut leakiness, endotoxemia and inflammatory liver injury.
6. It may also prevent injury by reducing endotoxin producing bacteria. (1)

1. Pomegranate prevents binge alcohol-induced gut leakiness and hepatic inflammation by suppressing oxidative and nitrative stress. Redox biology, Vol. 18 (September 2018), pp. 266-278 by Young-Eun E. Cho, Byoung-Joon J. Song



Related Posts: 
* Broccoli May Help Prevent "Leaky Gut" By Maintaining Good Intestinal Barrier Function! 
* Vitamin D Is Important For Intestinal Barrier Integrity And Control of Inflammation! 
*Probiotics May Reduce The Need For Antibiotics!

Gut Dysbiosis May Be A Factor in Chronic Fatigue Syndrome!

"Our results indicate dysbiosis of the gut microbiota in this disease and further suggest an increased incidence of microbial translocation, which may play a role in inflammatory symptoms in ME/CFS."

Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome. Microbiome, Vol. 4, No. 1. (23 June 2016) by Ludovic Giloteaux, Julia K. Goodrich, William A. Walters, et al.

Almonds! Good For the Heart And Good For The Gut!

"You know almonds: They’re the perennial nutritious food. In fact, you’d be hard-pressed to find someone who’s down on this tree nut." Read more...

What Are Almonds? A Detailed Guide to the Benefits of This Nutritious Tree Nut. Jessica Migala.

An Emerging Health Field: Nutritional Psychiatry!

"As evidence mounts for the existence of the gut-brain axis, nutritional psychiatry has emerged as a promising research field within the food and nutrition community. "Read more....

Nutritional psychiatry: Accessing the gut to address the brain.  17-Aug-2018 By Will Chu


 

Inflammation Starts in the Gut! Kick the High Fat Diet Habit!

In other posts, I have noted that one way to reduce the effects of environmental illnesses is to maintain a healthy diet that is low in fat. The main reasons for this is that high fat diets (HFD) 1) lead to dysbiosis. In other words, an unhealthy gut full of unhealthy gut bacteria and 2) HFD leads to obesity, more oxidative stress and inflammation that can lead to diabetes. (1-2)  Of course, since many patients with environmental illnesses already have higher oxidative stress. Anything that increases it is just going to make symptoms worse.

According to one recent study out of Chicago, researchers demonstrated that a HFD alters gut bacteria that makes fat gain easier. What they found is that "germ free" mice did not gain weight even when fed a HFD. On the other hand, mice with a "normal intestinal environment" and fed a HFD had an increase in bacteria that alter fat absorption and a decrease in bacteria linked to leanness. (3)

Browse The Catalog!

Related Post:
* Chemical in Broccoli May Help You Lose Weight!

*High-fat diet inhibits PGC-1α suppressive effect on NFκB signaling in hepatocytes. European journal of nutrition, Vol. 57, No. 5. (August 2018), pp. 1891-1900 by Wermerson Assunção A. Barroso, Vanessa Jacob J. Victorino, Isabela Casagrande C. Jeremias, et al.


1) Systemic low-grade inflammation is related to both circulating and adipose tissue TNFalpha, leptin and IL-6 levels in obese women. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, Vol. 28, No. 8. (August 2004), pp. 993-997 by M. Maachi, L. Piéroni, E. Bruckert, et al.

2. High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. PloS one, Vol. 5, No. 8. (16 August 2010) by Shengli Ding, Michael M. Chi, Brooks P. Scull, et al.

3).Gut bacteria Could Be One Reason a Junk Food Diet Makes Us Put on Weight. Sam Downing. Coach. Nine. Com. Au. April 12, 2018. https://coach.nine.com.au/2018/04/12/10/07/gut-bacteria-high-fat-diet

Chronic Fatigue Syndrome Linked to Abnormal Gut Bacteria!

Abnormal levels of specific gut bacteria are related to chronic fatigue syndrome/myalgic encephalomyelitis, or ME/CFS, in patients with and without concurrent irritable bowel syndrome, or IBS, scientists have discovered. Read more...

Columbia University's Mailman School of Public Health. "Chronic fatigue syndrome linked to imbalanced microbiome: Scientists identify abnormal levels of specific gut bacteria in individuals with chronic fatigue syndrome, including those with and without co-morbid IBS." ScienceDaily. ScienceDaily, 26 April 2017. <www.sciencedaily.com/releases/2017/04/170426092351.htm>.

Probiotics May Improve Cognition in Patients with Fibromyalgia!

"A small pilot study found that eight weeks of treatment with probiotics — live microorganisms thought beneficial to the gut microbiota — significantly helped to improve some aspects of cognition in fibromyalgia patients, like impulsive choice and decision-making." Read more,,,

Note: Indiscriminate use of probiotics may lead to brain fog and bloating in fibromyalgia. Ask your doctor.
         Related Post: Indiscriminate Use of Probiotics Leads to Brain Fog and Bloating!



Treating Gut Microbiome with Probiotics Seen to Aid Cognitive Abilities in Pilot Study. July 25, 2018. https://fibromyalgianewstoday.com/2018/07/25/treating-gut-microbiome-with-probiotics-aids-cognitive-abilities-in-pilot-study-in-fibromyalgia-patients/

Berries Improve Gut Health and are Protective Against Neuroinflammation!

Experts believe that gut dysbiosis is a cause of environmental illness. Changes in the gut biome can be caused by antibiotic use, environmental insults from chemicals in food and water and high fat and high sugar diets. These changes lead to morphological changes in the wall of the intestines that allows for easier translocation of harmful bacteria. It is believed that translocation may be one significant cause of chronic fatigue syndrome. In addition, it is believed that dysbiosis may lead to neuroinflammation that is believed to be a major source of symptoms in chronic fatigue and fibromyalgia.

Numerous studies published in the recent past have shown that consumption of some fruits and herbs may improve gut health. Research has demonstrated that anthocyanins in berries may counteract dysbiosis. In addition, they also have anti-neuroinflammatory properties and allow for better communication between the gut and the brain. Lastly, they alter tryptophan metabolism increasing the neuroprotective metabolite kynurenic acid. (1) Incidentally, this pathway also produces the antioxidant 3-hydroxyanthranilic acid which inhibits inflammatory proteins by activating Nrf2. (2) 





1. Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins. Scientific reports, Vol. 8, No. 1. (27 July 2018) by Cláudia Marques, Iva Fernandes, Manuela Meireles, et al.

2. 3-Hydroxyanthranilic acid, one of L-tryptophan metabolites, inhibits monocyte chemoattractant protein-1 secretion and vascular cell adhesion molecule-1 expression via heme oxygenase-1 induction in human umbilical vein endothelial cells. Atherosclerosis, Vol. 187, No. 2. (August 2006), pp. 274-284 by Hyun-Ock O. Pae, Gi-Su S. Oh, Bok-Soo S. Lee, et al.

Killing of Gut Biome Caused Brain Cell to Stop!

 

Antibiotics strong enough to kill off gut bacteria can also stop the growth of new brain cells in the hippocampus, a section of the brain associated with memory, reports a new study in mice. Researchers also uncovered a clue to why -- a type of white blood cell seems to act as a communicator between the brain, the immune system, and the gut.

 Cell Press. "Antibiotics that kill gut bacteria also stop growth of new brain cells." ScienceDaily. ScienceDaily, 19 May 2016. <www.sciencedaily.com/releases/2016/05/160519130105.htm>.

Antibiotics Promote Pathogen Growth By Disrupting Oxygen and Disturbing Gut Lining!

New research reveals further insights into the potential harm of antibiotic treatment by showing it can promote pathogens by disrupting oxygen levels and fiber processing in the gut lining.

 Antibiotics can promote 'bad' gut microbes by disrupting oxygen. Medical News Today. Catharine Paddock, PhD. May 4, 2016. http://www.medicalnewstoday.com/articles/309803.php?utm_campaign=trueAnthem:+Trending+Content&utm_content=572a02ba04d301094aa20a63&utm_medium=trueAnthem&utm_source=facebook