Probiotics May Improve Cognition in Patients with Fibromyalgia!

"A small pilot study found that eight weeks of treatment with probiotics — live microorganisms thought beneficial to the gut microbiota — significantly helped to improve some aspects of cognition in fibromyalgia patients, like impulsive choice and decision-making." Read more,,,

Note: Indiscriminate use of probiotics may lead to brain fog and bloating in fibromyalgia. Ask your doctor.
         Related Post: Indiscriminate Use of Probiotics Leads to Brain Fog and Bloating!



Treating Gut Microbiome with Probiotics Seen to Aid Cognitive Abilities in Pilot Study. July 25, 2018. https://fibromyalgianewstoday.com/2018/07/25/treating-gut-microbiome-with-probiotics-aids-cognitive-abilities-in-pilot-study-in-fibromyalgia-patients/

Connection Between Oxidative Stress and Inflammation Proteins in Fibromyalgia!

"Two proteins linked to inflammation and oxidative stress are deregulated in blood samples of fibromyalgia (FM) patients compared with healthy controls, according to findings from a large-scale protein analysis." Read more....

Two Proteins Identified as Potential Markers for Fibromyalgia in Large-Scale Analysis, Study Reports. Patricia Ignacio. July 24, 2018. https://fibromyalgianewstoday.com/2018/07/24/protein-analysis-identifies-potential-fibromyalgia-biomarkers-study/?utm_content=buffer07ebe&utm_medium=organic+social&utm_source=facebook.com&utm_campaign=buffer

Berries Improve Gut Health and are Protective Against Neuroinflammation!

Experts believe that gut dysbiosis is a cause of environmental illness. Changes in the gut biome can be caused by antibiotic use, environmental insults from chemicals in food and water and high fat and high sugar diets. These changes lead to morphological changes in the wall of the intestines that allows for easier translocation of harmful bacteria. It is believed that translocation may be one significant cause of chronic fatigue syndrome. In addition, it is believed that dysbiosis may lead to neuroinflammation that is believed to be a major source of symptoms in chronic fatigue and fibromyalgia.

Numerous studies published in the recent past have shown that consumption of some fruits and herbs may improve gut health. Research has demonstrated that anthocyanins in berries may counteract dysbiosis. In addition, they also have anti-neuroinflammatory properties and allow for better communication between the gut and the brain. Lastly, they alter tryptophan metabolism increasing the neuroprotective metabolite kynurenic acid. (1) Incidentally, this pathway also produces the antioxidant 3-hydroxyanthranilic acid which inhibits inflammatory proteins by activating Nrf2. (2) 





1. Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins. Scientific reports, Vol. 8, No. 1. (27 July 2018) by Cláudia Marques, Iva Fernandes, Manuela Meireles, et al.

2. 3-Hydroxyanthranilic acid, one of L-tryptophan metabolites, inhibits monocyte chemoattractant protein-1 secretion and vascular cell adhesion molecule-1 expression via heme oxygenase-1 induction in human umbilical vein endothelial cells. Atherosclerosis, Vol. 187, No. 2. (August 2006), pp. 274-284 by Hyun-Ock O. Pae, Gi-Su S. Oh, Bok-Soo S. Lee, et al.

Paraquat Produces Oxidative Stress in Dose-dependant Manner. Implications for Nrf2.

It was determined through a new study that exposure to dose dependent levels of Paraquat is responsive for increasing levels of oxidative stress. At lower level, production of oxidative stress was reduced by activation of the Nrf2. At higher dose levels, Nrf2 activation was inhibited which resulted in higher levels of oxidative stress and tissue damage.

This is important because Paraquat is an important agricultural herbicide that is used around the world. There are numerous reports that it crosses the blood brain barrier and accumulates in different brain regions. Because of this, it is believed that it does damage to dopamine neurons. It has also been found to cross the placenta and has been found in higher concentrations in the placenta than in the mother's blood. For this reason, the exposure to Paraquat may put a fetus at risk when the mother is exposed. In addition, Paraquat exposure has been linked to Parkinson's disease and Nrf2 inhibition at higher levels may to be blame for development of the disease. Of course, since oxidative stress is caused by exposure to Paraquat, people that have diseases or conditions where oxidative stress is a factor may be more negatively effected. (1)


Nrf2/ARE Pathway Involved in Oxidative Stress Induced by Paraquat in Human Neural Progenitor Cells. Oxidative medicine and cellular longevity, Vol. 2016 (2016) by Tingting Dou, Mengling Yan, Xinjin Wang, et al. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663008/

Nitric Oxide Synthase Might Be Used for Diagnosis of Environmental Illness!

"Genetic polymorphisms may explain what individual get what idiopathic environmental disease. The author of this new study demonstrates how he is able to differentiate patients with MCS, FM and CFS by genetic differences in nitric oxide synthase. He concludes that screening using NOS may be available and useful for diagnosis of disease." 

Role of polymorphisms of inducible nitric oxide synthase and endothelial nitric oxide synthase in idiopathic environmental intolerances. Mediators of inflammation, Vol. 2015 (2015) by Chiara De Luca, Agnese Gugliandolo, Carlo Calabrò, et al. http://www.citeulike.org/user/kimberlykramer2015/article/13584669