Vitamin D Is Important For Intestinal Barrier Integrity And Control of Inflammation!

"Vitamin D reduces the permeability of intestinal cells in animal models of colitis. In VDR knock-out mice, dextran sodium sulfate induces colitis that is associated with decreased immunostaining of zonula occludens-1 and occluding proteins on epithelial cells of the colon and associated with decreased transepithelial resistance and increased permeability. The nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is an intracellular pattern recognition receptor. It activates NF-kB and increases Vitamin D-mediated transcription of cathelicidin and DEFB4 (defensin, beta 4). If the innate immune system cannot control the microbiome, it could be lead to tissue inflammation." (1)

 Vitamin D, the gut microbiome and inflammatory bowel disease. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, Vol. 23 (2018) by Seyed-Amir A. Tabatabaeizadeh, Niayesh Tafazoli, Gordon A. Ferns, Amir Avan, Majid Ghayour-Mobarhan http://www.citeulike.org/user/kimberlykramer2015/article/14633504