Short-Chain Fatty Acids From the Diet Can Help Repair Intestinal Barrier Integrity!

A new study demonstrated that short chain fatty acids can alleviate intestinal permeability from lipopolysaccharides of gram negative bacteria by inhibiting autophagy and the inflammasome. In addition, they can stimulate the formation of the intestinal barrier function. Intestinal barrier dysfunction has been implicated in a number of environmental illness including chronic fatigue syndrome (CFS) and irritable bowel syndrome. It was recently reported that the inflammasome may be implicated in some patients with CFS. (1)

    Just a few natural examples of short-chained fatty acids are: (2)

1. Resistant starches from whole-grain cereals, barley, brown rice, beans, lentils, green bananas, cooked and cooled potatoes or pasta
2. Pectin from apples, apricots, blackberries, carrots and oranges
3. Fructooligosaccharides (FOS) and inulin from Jerusalem artichokes, onions, leeks, wheat, rye and asparagus
4. Arabinoxylan
5. Guar gum

1. Short-Chain Fatty Acids Manifest Stimulative and Protective Effects on Intestinal Barrier Function Through the Inhibition of NLRP3 Inflammasome and Autophagy. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 49, No. 1. (23 August 2018), pp. 190-205 by Yanhai Feng, Yu Wang, Pei Wang, Yalan Huang, Fengjun Wang.

2. NutrientsReview.com