Pomegranate As Part Of A Healthy Diet May Prevent "Leaky Gut"!

Photo by Charles Deluvio 🇵🇭🇨🇦 on Unsplash

In a recent study, it was demonstrated that ingestion of pomegranates for 10 days led to a decrease in gut leakiness, endotoxemia and inflammatory liver damage from binge drinking. Although most people do not binge drink, it is safe to assume that adding pomegranate to one's diet may help prevent anything that causes "leaky gut syndrome". Just a few of these causes include bacterial infections,
Western-type diets and high sugar diets. "Leaky gut" has been implicated in a number of health conditions including chronic fatigue syndrome, fibromyalgia, inflammatory bowel disease, diabetes and many others.

The results of this study showed:

1. POM protected the alcohol-induced gut leakiness and inflammatory liver injury through suppressing the nitroxidative stress with elevated levels of CYP2E1, iNOS and nitrated proteins in the intestines and livers of the alcohol-exposed rats. 
2. POM pretreatment prevented hepatic injury, fat accumulation, nitroxidative stress and ER stress and inflammation response in the liver and allowed for blockade of gut leakiness in alcohol-exposed rates. 
3.  Pretreatment with an individual compound of POM EA or UA significantly reduced the elevated levels of CYP2E1, iNOS and nitrated proteins as well as the mRNA transcripts of NLRP3, IL-1β, and TNF-α in alcohol-exposed AML12 liver cells.
4. Protected against tight junction disfunction by increasing tight junction proteins. 
5. The author believes that the reduction of CYP2E1 prevented gut leakiness, endotoxemia and inflammatory liver injury.
6. It may also prevent injury by reducing endotoxin producing bacteria. (1)

1. Pomegranate prevents binge alcohol-induced gut leakiness and hepatic inflammation by suppressing oxidative and nitrative stress. Redox biology, Vol. 18 (September 2018), pp. 266-278 by Young-Eun E. Cho, Byoung-Joon J. Song



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