Showing posts with label depression. Show all posts
Showing posts with label depression. Show all posts

Thursday, November 15, 2018

Depression Medications May Treat Dementia!

People with a diagnosis of dementia can also face depression. For this reason, they may end up taking antidepressant drugs. Now, a study has found that these drugs may be able to treat not just depression, but dementia itself. Read more...




Antidepressants could stave off dementia. Maria Cohut. Medical News Today. 
Published Monday 15 October 2018

Friday, November 9, 2018

Researchers Find A Path To Depression In The Brain!



Scientists may have caught a glimpse of what sadness looks like in the brain.

A study of 21 people found that for most, feeling down was associated with greater communication between brain areas involved in emotion and memory, a team from the University of California, San Francisco reported Thursday in the journal Cell.Read more..






Researchers Uncover A Circuit For Sadness In The Human Brain. NPR. November 8, 2018

Sunday, October 21, 2018

Compound In Chili Peppers Reduces Depression Symptoms!




"A substance found in chili peppers reduces depressive symptoms in a rodent model of depression, according to research published in Physiology & Behavior. The study examined the effects of capsaicin, which is responsible for the spicy and pungent flavor of chilis. " Read more...





Capsaicin from chili peppers found to produce antidepressant-like effects in rats. PsychPost.com.
By Eric W. Dolan October 14, 2018

Monday, October 15, 2018

Biological Basis For Depression, Anxiety And Sleep Disorders Suggested!




"UC San Francisco researchers, in collaboration with the unique Brazilian Biobank for Aging Studies (BBAS) at the University of São Paulo, have shown that the earliest stages of the brain degeneration associated with Alzheimer's disease (AD) are linked to neuropsychiatric symptoms including anxiety, depression, loss of appetite, and sleep disturbances. " Read more...





Study suggests biological basis for depression, anxiety, sleep disturbances in older adults .
October 15, 2018 by Nicholas Weiler, University of California, San Francisco

Wednesday, October 10, 2018

Winter Blues Study Finds Keys To Why Some Do Not Develop Depression!



"A new study used a model of seasonal affective disorder to find out why some people don't develop depression despite being genetically predisposed to it. The findings also shed light on potential new treatments for seasonal depression." Read article...




'Winter blues' study finds key to depression resilience . Ana Sandoiu . Medical News
Today. 10/7/2018.

Tuesday, October 9, 2018

Depression And Childhood Trauma Can Make You Age Faster!



"  A new study has found that people living with major depressive disorder are biologically older than people without depression, and that childhood trauma exacerbates this effect. The results illuminate the epigenetic mechanisms that might explain this discrepancy." Read article...




Why depression, trauma can make you age faster. Ana Sandoui, Medical news Today. 10/9/2018. 




Thursday, September 27, 2018

The Mediterranean Diet May Help Prevent Depression!




"The age-defying benefits of the Mediterranean diet are already well documented. A diet consisting of fresh vegetables, fruit, grains, olive oil and minimal meat works wonders for your body and its ability to cope with old age." Read more..




The Mediterranean diet could fight depression. The secret to a longer (and happier) life?
Men's Health.  Posted on September 26, 2018

Wednesday, September 26, 2018

Depression More Than Doubles The Risk For Lupus!





"A history of depression is associated with more than double the risk of developing systemic lupus erythematosus (SLE) among women, new research suggests." Read more...







Depression Tied to Double the Risk for Lupus in Women. Pauline Anderson. Medscape. September 25, 2018

Thursday, September 20, 2018

Weight Training Can Reduce Symptoms Of Depression!



"Aerobic exercise has been linked with reducing symptoms of depression, but resistance training, such as weight lifting and bodyweight exercises like push-ups, can have the same effect." Read more...


Lifting weights might lift your mood. Harvard Publishing. August, 2018.

Monday, September 17, 2018

Depression In Children May Look Different Than In Adults!



Photo by Liliia Beda on Unsplash


"When we think of a depressed person, we tend to think of someone who, well, acts sad. The picture we have in our head is of someone who doesn’t want to get off the couch or out of bed, who is eating much less or much more than usual, has trouble sleeping or wants to sleep all the time, who has trouble with usual daily activities, and doesn’t talk much." Read more...


In children and teens, depression doesn’t always look like sadness Updated March 14, 2018, 11:53 am.Claire McCarthy, MD. Harvard Health Publishing.

Saturday, September 15, 2018

Probiotics May Improve Cognitive Function And Boost Your Mood!



Probiotics can do more than improve your gut health. They also may indirectly enhance your brain, too.



Research shows that the gut and brain are connected, a partnership called the gut-brain axis. The two are linked through biochemical signaling between the nervous system in the digestive tract, called the enteric nervous system, and the central nervous system, which includes the brain. The primary information connection between the brain and gut is the vagus nerve, the longest nerve in the body. Read more...




Probiotics may help boost mood and cognitive function. Harvard Publishing. https://www.health.harvard.edu/mind-and-mood/probiotics-may-help-boost-mood-and-cognitive-function?utm_content=bufferd858b&utm_medium=social&utm_source=twitter&utm_campaign=buffer

Thursday, September 13, 2018

Mitochondrial Stress May Cause An Immune Response, Inflammation and Depression!




"Humans and other mammals react to stressful situations through a series of well-orchestrated evolutionary adaptations. When faced with a predator looking for its next meal, or with worry of losing a job, our bodies release a cascade of stress hormones. Our heart rate spikes, breath quickens, muscles tense up and beads of sweat appear." Read more...




Brain’s Dumped DNA May Lead to Stress, Depression. New research suggests genetic material from the mitochondria can trigger an immune response throughout the body. Knvul Sheikh. Scientific American. September 13, 2018

Wednesday, September 5, 2018

Mindfulness Meditation May Help Relieve Depression!





"A new study reveals that eight weeks of mindfulness meditation may help to prevent major depresssive disorder in people with subclinical depression." Read more...




Could mindfulness prevent major depression? Honor Whiteman. Medical News Today. March 14, 2018. https://www.medicalnewstoday.com/articles/321215.php

Saturday, September 1, 2018

Diet is Important for Treating Depression!



"Just this week, I have seen three patients with depression requiring treatment. Treatment options include medications, therapy, and self-care. Self-care includes things like sleep, physical activity, and diet, and is just as important as meds and therapy — sometimes more so." Read more...





Diet and depression. Monique Tello, MD, MPH. February 22, 2018. Harvard Health Publishing.  https://www.health.harvard.edu/blog/diet-and-depression-2018022213309?utm_content=buffer106a1&utm_medium=social&utm_source=twitter&utm_campaign=buffer


Monday, August 27, 2018

Depression Changes the Brain Over Time!




"Is clinical depression a degenerative illness? One new study shows that inflammation in the brain linked to depression increases over time. " Read more...





Long Term Depression Permanently Changes the Brain. Chelsea Gohd. Futurism. February 27, 2018. 



Sunday, August 26, 2018

Broccoli Compound May Be Therapeutic Against Depression Associated With Chronic Pain!






Depression is often found in patients that suffer from chronic pain. In fact, that percentage ranges from 30% to 50%. It has also been shown that the Nrf2 is decreased in patients that suffer from depression. Nrf2 is the "master regulator" of the antioxidant system which regulates over 200 genes. These genes include those for neutralizing oxidative stress, mitochondrial biogenesis and adipogenesis. In addition, it has been found that it plays an inhibitory role in inflammation.

The Nrf2 system can be activated by a number of food supplements and natural compounds. Past studies have demonstrated that sulforaphane, a compound found in broccoli and cabbage, had beneficial effect on inflammation-induced depression. Also, it may reduce symptoms of allodynia and hyperalgesia which are two symptoms common in fibromyalgia and pain conditions. In a rat model of neuropathic pain (spinal nerve injury) in a new 2018 study, researchers demonstrated that the animals exhibited nociceptive damage and anhedonia-like phenotypes. They also found lower levels of Nrf2 in the spinal cord and livers of these animals. Treatment with sulforaphane before injury resulted in amelioration of anhedonia-like behaviors and reduced lower levels of Nrf2 in the brain and spinal cord in rats with anhedonia-like phenotypes. Treatment after injury demonstrated significantly higher levels of Nrf2 and a decrease in mechanical withdrawal threshold score. This was the first study to show that Nrf2 impacts anhedonia after neuropathic pain and that sulforaphane may be therapeutic in depression when associated with neuropathic pain. (1)






1. Role of Keap1-Nrf2 Signaling in Anhedonia Symptoms in a Rat Model of Chronic Neuropathic Pain: Improvement With Sulforaphane. Frontiers in pharmacology, Vol. 9 (2018) by Shan Li, Chun Yang, Xi Fang, et al. https://www.frontiersin.org/articles/10.3389/fphar.2018.00887/full



Tuesday, August 21, 2018

The Microbiome Plays A Big Part In How We Handle Stress!


"The microbiome plays a key role in determining how different individuals respond to psychological and physical stress, researchers have concluded. " Read more...






Microbiome seen as key factor in resilience/immunity equation.  16-Aug-2018 By Hank Schultz. https://www.nutraingredients.com/Article/2018/08/16/Microbiome-seen-as-key-factor-in-resilience-immunity-equation 

Monday, August 13, 2018

A Biomarker for Depression May Be Acetyl-L-carnitine (LAC)!




"Low blood levels of acetyl-L-carnitine (LAC) may be a biomarker for major depressive disorder (MDD), new research suggests." Read more...


 Low Acetyl-L-Carnitine a New Biomarker for Major Depression? - Medscape - Aug 02, 2018.

Thursday, August 2, 2018

Broccoli May Have Health Benefits in People with Chronic Fatigue Syndrome!








In past blogs, we have discussed the many benefits of eating broccoli which contains the isothiocyanate sulforaphane. Past discussions have focused on how it may reduce inflammation that leads to cancer and depression and be beneficial in the treatment of other diseases.  It has now been shown that it acts directly on the inflammasome NLRP3 by inhibiting the maturation of Il-1b. Interestingly, this discovery represents a new pathway for sulfurophane's action because in this case, its action is independent of Nrf2. (2)  

A recent study has demonstrated that in a mouse model of chronic fatigue syndrome, fatigue was caused by activation of the inflammasome NLRP3. Inflammasomes are sensing protein complexes that are part of the immune response. that eventually produces Il-1 and Il-6. In the model, mice were exposed to an LPS challenge and a swim test. After the experiment, test mice showed an increase of both Il-1 and Il-6 in the brain and behaviorally, slower motor responses. The author wrote, "LPS-induced fatigue is an Il-1-dependent process and the NLRP3/caspase-1 pathway is involved in the mechanism of LPS-induced fatigue behaviors. NLRP3/caspase-1 inhibition may be a promising therapy for fatigue treatment. " (1)


Related Posts: 
*Depression in Environmental Illness May Be Relieved by Eating Broccoli! 

What's Next:
* Nrf2 and inflammasomes.
1. Activation of the NLRP3 inflammasome in lipopolysaccharide-induced mouse fatigue and its relevance to chronic fatigue syndrome. Journal of neuroinflammation, Vol. 13, No. 1. (05 April 2016) by Zi-Teng T. Zhang, Xiu-Ming M. Du, Xiu-Juan J. Ma, et al. http://www.citeulike.org/user/kimberlykramer2015/article/14620278

2. Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism. Journal of leukocyte biology, Vol. 99, No. 1. (January 2016), pp. 189-199 by Allison J. Greaney, Nolan K. Maier, Stephen H. Leppla, Mahtab Moayeri. 

Monday, July 30, 2018

Depression in Environmental Illness May Be Relieved by Eating Broccoli!




"Depressive symptoms in environmental illnesses are more likely due to activation of TNF-a which presents as "sickness behavior". It would account for the fatigue and the depression. Because sulforaphane enhances expression of Nrf2, depressive symptoms may be relieved by prophylactic ingestion of broccoli. While some think that the depression is caused by activation of the corticosteroid system, I do not agree." If nothing else, it is worth the try!


 Prophylactic effects of sulforaphane on depression-like behavior and dendritic changes in mice after inflammation. The Journal of nutritional biochemistry, Vol. 39 (January 2017), pp. 134-144 by Ji-Chun C. Zhang, Wei Yao, Chao Dong, et al. http://www.citeulike.org/user/kimberlykramer2015/article/14619968