Controlling Microglia Activity May Benefit Those With Neurodegenerative Disease!

"A group of Massachusetts General Hospital (MGH) investigators is proposing that targeting immune checkpoints—molecules that regulate the activity of the immune system—in immune cells called microglia could reduce the inflammatory aspects of important neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis (ALS)." Read more...

Regulating microglial activity may reduce inflammation in neurodegenerative diseases.
October 17, 2018, Massachusetts General Hospital

Bipolar and Depression Could Be Caused by Dysregulation in the Body's Antioxidant System

"Although bipolar disorder and depression are not found at this time in the NRF2 diseasome, it is becoming evident that they exhibit neuroinflammatory and degenerative pathophenotypes that at least in mouse models imply deregulation of NRF2". 

         Systems Medicine Approach to NRF2 in Chronic Diseases 375. NRF2 (Martin-de-Saavedra et al., 2013; Freitas et              al., 2016; Yao et al., 2016).

TLR4 Activity in the Gut Contributes to Symptoms in Chronic Fatigue Syndrome!

"Interactions between gut microorganisms and host immune function have been shown to contribute to aberrant inflammation in CFS/ME patients. Commensal and/or pathogen-associated molecular patterns detected by Toll-like receptors (TLRs) expressed on intestinal epithelial cells appear to trigger inflammatory signaling cascade leading to neuroinflammation and neurodegeneration."

The Role of Toll-like Receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A New Promising Therapeutic Approach? CNS & neurological disorders drug targets (25 March 2015) by M. E. Gambuzza, F. M. Salmeri, L. Soraci, et al.  http://www.citeulike.org/user/kimberlykramer2015/article/13568646


For further reading:
Infection/Endotoxin in Chronic Fatigue, Fibromyalgia and Multiple Chemical Sensitivity.