Fatigue as a Consequence of Changes In Cellular Metabolism and Disturbed Sleep!

In a recent article the author writes, "persistent fatigue may be a consequence of chronic low-grade inflammation leading to an imbalance in energy availability and expenditure, which can be mediated and maintained by changes in circadian rhythms and sleep. He goes on to say that associations between persistent fatigue in CFS and CRF with alterations in cellular metabolism, disturbed sleep, and, to a lesser extent, disruptions in circadian rhythm. For both CRF (cancer-relate fatigue) and CFS, multi-causal models are generally suggested including low-grade inflammation and disturbed sleep, and also alterations in stress physiological responses, genetic vulnerability, and sociodemographic factors, among others. " 




The High Costs of Low-Grade Inflammation: Persistent Fatigue as a Consequence of Reduced Cellular-Energy Availability and Non-adaptive Energy Expenditure. Frontiers in behavioral neuroscience, Vol. 12 (2018) by Tamara E. Lacourt, Elisabeth G. Vichaya, Gabriel S. Chiu, Robert Dantzer, Cobi J. Heijnen